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LAG-3: a very singular immune checkpoint

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The mechanism of action of the lymphocyte checkpoint protein LAG-3 was always rather mysterious. It now seems to operate at least in part by recognizing and suppressing responses to stable complexes of peptide and major histocompatibility complex class II.

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Fig. 1: The binding of LAG-3 and expression of MHC class II do not always match.

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Authors and Affiliations

  1. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK

    Yuan Lui & Simon J. Davis

  2. Radcliffe Department of Medicine, University of Oxford, Oxford, UK

    Simon J. Davis

Authors
  1. Yuan Lui
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  2. Simon J. Davis
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Correspondence to Simon J. Davis.

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Lui, Y., Davis, S.J. LAG-3: a very singular immune checkpoint. Nat Immunol 19, 1278–1279 (2018). https://doi.org/10.1038/s41590-018-0257-1

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