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Neuroimmunology

Targeting fibrin in neurodegeneration

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Deposition of fibrin in the brain and central nervous system occurs after injury or disease. This process unmasks a conserved cryptic epitope of fibrin that activates microglia; blocking this interaction can limit inflammation and neurotoxicity.

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Fig. 1: Physiological and pathological functions of fibrin, and the amino-acid positions relevant for fibrin polymerization (γ400–411) and the cryptic loop, which mediates the activation of innate immunity and is targeted by mAb 5B8 (γ377–395).

References

  1. Ryu, K.R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0232-x (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Lassmann, H., van Horssen, J. & Mahad, D. Rev. Neurol. 8, 647–656 (2012).

    Article  CAS  Google Scholar 

  3. Colvin, R. B. & Dvorak, H. F. J. Exp. Med. 142, 1377–1390 (1975).

    Article  CAS  PubMed  Google Scholar 

  4. Melchor, J. P. & Strickland, S. Thromb. Haemost. 93, 655–660 (2005).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Adams, R. A., Passino, M., Sachs, B. D., Nuriel, T. & Akassoglou, K. Mol. Interv. 4, 163–176 (2004).

    CAS  PubMed  Google Scholar 

  6. Cortes-Canteli, M., Zamolodchikov, D., Ahn, H. J., Strickland, S. & Norris, E. H. J. Alzheimers Dis. 32, 599–608 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sobel, R. A. & Mitchell, M. E. Am. J. Pathol. 135, 161–168 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Satoh, J. et al. J. Immunol. 138, 179–184 (1987).

    CAS  PubMed  Google Scholar 

  9. Koh, C.-S. & Paterson, P. Y. Cell. Immunol. 107, 52–63 (1987).

    Article  CAS  PubMed  Google Scholar 

  10. Ansari, M. A. & Scheff, S. W. J. Neuropathol. Exp. Neurol. 69, 155–167 (2010).

    Article  CAS  PubMed  Google Scholar 

  11. Sims, R. et al. Nat. Genet. 49, 1373–1384 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Cuyvers, E. & Sleegers, K. Lancet Neurol. 15, 857–868 (2016).

    Article  CAS  PubMed  Google Scholar 

  13. Mestas, J. & Hughes, C. C. J. Immunol. 172, 2731–2738 (2004).

    Article  CAS  PubMed  Google Scholar 

  14. Takada, Y. et al. J. Autoimmun. 34, 453–459 (2010).

    Article  CAS  PubMed  Google Scholar 

  15. Luo, D. et al. J. Immunol. 190, 4149–4161 (2013).

    Article  CAS  PubMed  Google Scholar 

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  1. Neuroimmunology and Multiple Sclerosis Research, Neurology Clinic, University Hospital Zurich, University Zurich, Zurich, Switzerland

    Roland Martin

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  1. Roland Martin
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Correspondence to Roland Martin.

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Martin, R. Targeting fibrin in neurodegeneration. Nat Immunol 19, 1149–1150 (2018). https://doi.org/10.1038/s41590-018-0241-9

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