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MEMORY T CELLS

An RNA checkpoint that keeps immunological memory at bay

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What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.

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Fig. 1: The discriminatory functions of members of the ZFP36 family during effector and memory T cell responses.

Marina Corral Spence/Springer Nature

References

  1. Chang, J. T., Wherry, E. J. & Goldrath, A. W. Nat. Immunol. 15, 1104–1115 (2014).

    Article  CAS  Google Scholar 

  2. Mueller, S. N. & Mackay, L. K. Nat. Rev. Immunol. 16, 79–89 (2016).

    Article  CAS  Google Scholar 

  3. Salerno, F. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0155-6 (2018).

    Article  CAS  Google Scholar 

  4. Salerno, F., Paolini, N. A., Stark, R., von Lindern, M. & Wolkers, M. C. Proc. Natl Acad. Sci. USA 114, 9677–9682 (2017).

    Article  CAS  Google Scholar 

  5. Kafasla, P., Skliris, A. & Kontoyiannis, D. L. Nat. Immunol. 15, 492–502 (2014).

    Article  CAS  Google Scholar 

  6. Turner, M. & Díaz-Muñoz, M. D. Nat. Immunol. 19, 120–129 (2018).

    Article  CAS  Google Scholar 

  7. Wells, M. L., Perera, L. & Blackshear, P. J. Trends Biochem. Sci. 42, 285–296 (2017).

    Article  CAS  Google Scholar 

  8. Moore, M. J. et al. eLife 7, e33057 (2018).

    Article  Google Scholar 

  9. Zhang, X., Chen, X., Liu, Q. & Zhang, S. eLife 6, e27786 (2017).

    Article  Google Scholar 

  10. Villarino, A. V. et al. Immunity 34, 50–60 (2011).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Aristotle University of Thessaloniki, School of Biology, Department of Genetics, Development & Molecular Biology, Thessaloniki, Greece

    Dimitris L. Kontoyiannis

  2. Biomedical Sciences Research Centre ‘Alexander Fleming’, Division of Immunology, Vari, Greece

    Dimitris L. Kontoyiannis

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  1. Dimitris L. Kontoyiannis
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Correspondence to Dimitris L. Kontoyiannis.

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Kontoyiannis, D.L. An RNA checkpoint that keeps immunological memory at bay. Nat Immunol 19, 795–797 (2018). https://doi.org/10.1038/s41590-018-0168-1

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