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Age-associated B cells

Age-associated B cells acquire a new wrinkle

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SWAP-70 and DEF6 prevent the cytokine IL-21–induced transcription factor IRF5 from binding to DNA and recruiting the transcription factor T-bet and thereby diminish the activation of age-associated B cells.

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Fig. 1: Resting and activated ABCs.

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Authors and Affiliations

  1. Center for Autoimmunity, Musculoskeletal and Hematologic Diseases, Feinstein Institute for Medical Research, Manhasset, New York, NY, USA

    Yong-Rui Zou & Anne Davidson

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  1. Yong-Rui Zou
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  2. Anne Davidson
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Correspondence to Anne Davidson.

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The authors declare no competing interests.

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Zou, YR., Davidson, A. Age-associated B cells acquire a new wrinkle. Nat Immunol 19, 317–318 (2018). https://doi.org/10.1038/s41590-018-0072-8

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