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Cancer immunoevasion

Another way to not get eaten

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A previously unknown role is identified for a pathway that involves major histocompatibility complex class I and an inhibitory receptor, LILRB1, that regulates the phagocytosis of cancer cells by macrophages and contributes to resistance directed against the signal-regulatory protein CD47.

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Fig. 1: CD47–SIRPα and MHC class I–LILRB1 are independent yet cooperative anti-phagocytic signals.

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Correspondence to Yang-Xin Fu.

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Zhang, C.C., Fu, YX. Another way to not get eaten. Nat Immunol 19, 6–7 (2018). https://doi.org/10.1038/s41590-017-0009-7

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