Ferroptosis, a cell death mechanism induced by lipid peroxidation, is pivotal in tumor suppression. A recent study shows that tumor repopulating cells evade ferroptosis and develop resistance to therapy via subverting a lipid metabolism enzyme.
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B.G. is an inventor on patent applications involving targeting ferroptosis in cancer therapy, and reports personal fees from Guidepoint Global, Cambridge Solutions, and NGM Bio. Y.Y. has no declaration of interests.
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Yan, Y., Gan, B. Dodging death. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01607-3
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DOI: https://doi.org/10.1038/s41589-024-01607-3
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