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Bringing chemistry to medicine to redefine the undruggable

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Chemical approaches, such as those that leverage induced proximity, targeted degradation, synthetic gene regulators or protein design offer opportunities to therapeutically target cellular processes that have long been thought of as undruggable. We report on the progress and the potential for transformative collaborations between fields discussed at the 2023 Bringing Chemistry to Medicine symposium at St. Jude Children’s Research Hospital.

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Fig. 1: Overview of the topics covered at the 2023 C2M conference.

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Authors and Affiliations

  1. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Caitlin D. Deane, Marcus Fischer & Anang A. Shelat

Authors
  1. Caitlin D. Deane
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  2. Marcus Fischer
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  3. Anang A. Shelat
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Corresponding authors

Correspondence to Caitlin D. Deane, Marcus Fischer or Anang A. Shelat.

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The authors declare no competing interests.

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Deane, C.D., Fischer, M. & Shelat, A.A. Bringing chemistry to medicine to redefine the undruggable. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01598-1

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  • DOI: https://doi.org/10.1038/s41589-024-01598-1

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