Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with predicting potential pathways of resistance. A new analytical method for evaluating chemogenetic profiles reveals contributions from death-regulatory genes.
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References
Honeywell, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01584-7 (2024).
Colic, M. & Hart, T. Comput. Struct. Biotechnol. J. 17, 1318–1325 (2019).
Bock, C. et al. Nat. Rev. Methods Primers 2, 8 (2022).
Bae, S. Y. et al. Cell Death Dis. 11, 255 (2020).
Richards, R. et al. Nat. Chem. Biol. 16, 791–800 (2020).
Schwartz, H. R. et al. Cell Rep. 31, 107800 (2020).
Kastenhuber, E. R. & Lowe, S. W. Cell 170, 1062–1078 (2017).
Lowe, S. W. et al. Cell 74, 957–967 (1993).
Villunger, A. et al. Science 302, 1036–1038 (2003).
Hadian, K. & Stockwell, B. R. Nat. Rev. Drug Discov. 22, 723–742 (2023).
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Gelles, J.D., Chipuk, J.E. The death gaze of MEDUSA. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01594-5
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DOI: https://doi.org/10.1038/s41589-024-01594-5
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