Cyclic tetrapeptides (CTPs) have great potential for materials and therapeutics; however, synthesizing these molecules remains a significant challenge. Now, an enzyme has been developed that enables efficient N-to-C cyclization of linear tetrapeptidyl substrates to form structurally diverse CTPs.
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References
Sarojini, V., Cameron, A. J., Varnava, K. G., Denny, W. A. & Sanjayan, G. Chem. Rev. 119, 10318–10359 (2019).
Kuranaga, T. et al. Angew. Chem. Intl Ed. Engl. 57, 9447–9451 (2018).
Zhou, Y. et al. Cell Chem. Biol. 26, 737–744.e4 (2019).
Thankachan, D. et al. ACS Chem. Biol. 14, 845–849 (2019).
Fazal, A., Webb, M. E. & Seipke, R. F. Antibiotics (Basel) 9, 452 (2020).
Matsuda, K. et al. Org. Biomol. Chem. 17, 1058–1061 (2019).
Matsuda, K. et al. Nat. Catal. 3, 507–515 (2020).
Matsuda, K., Fujita, K. & Wakimoto, T. J. Ind. Microbiol. Biotechnol. 48, kuab023 (2021).
Fazal, A., Wheeler, J., Webb, M. E. & Seipke, R. F. Org. Biomol. Chem. 20, 7232–7235 (2022).
Kobayashi, M., Fujita, K., Matsuda, K. & Wakimoto, T. J. Am. Chem. Soc. 145, 3270–3275 (2023).
Budimir, Z. L. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01495-z (2024).
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Su, L., Deng, H. Size matters. Nat Chem Biol 20, 8–10 (2024). https://doi.org/10.1038/s41589-023-01503-2
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DOI: https://doi.org/10.1038/s41589-023-01503-2
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