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Targeted protein degradation

Proximity-inducing pharmacology

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Controlled interactions between macromolecules are fundamental regulatory layers. Hijacking these circuits via proximity-inducing small molecules offers many therapeutic opportunities. The organizers, Georg Winter and Cristina Mayor-Ruiz, report on the latest trends in this emerging field discussed at the 39th IRB-BioMed Conference in Barcelona.

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Fig. 1: Attendees at the 39th IRB-BioMed Conference,“Proximity-inducing pharmacology: targeted protein degradation and beyond,” held in Barcelona on 22–25 May 2023.

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Author information

Authors and Affiliations

  1. Research Center for Molecular Medicine (CeMM), Austrian Academy of Sciences, Vienna, Austria

    Georg E. Winter

  2. Institute for Research in Biomedicine (IRB) Barcelona, Barcelona Institute of Technology (BIST), Barcelona, Spain

    Cristina Mayor-Ruiz

Authors
  1. Georg E. Winter
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  2. Cristina Mayor-Ruiz
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Corresponding authors

Correspondence to Georg E. Winter or Cristina Mayor-Ruiz.

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Competing interests

G.E.W. is a scientific founder and shareholder of Proxygen and Solgate. His lab has received research funding from Pfizer. C.M.-R. is part of the scientific advisory board of Nostrum Biodiscovery. Her lab has received or receives sponsored research support from Almirall and Aelin Tx.

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Winter, G.E., Mayor-Ruiz, C. Proximity-inducing pharmacology. Nat Chem Biol 20, 13–14 (2024). https://doi.org/10.1038/s41589-023-01492-2

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