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Redox metabolism

Toying with reductive stress

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Genetically encoded tools to manipulate redox metabolism are in high demand for investigating the underlying mechanism of cofactor imbalances in mammalian systems. A new tool enables the induction and interrogation of NADH reductive stress.

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Fig. 1: A genetically encoded tool to interrogate cellular NADH reductive stress.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA

    Alexandria C. Murphy & Melanie R. McReynolds

  2. Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA

    Melanie R. McReynolds

Authors
  1. Alexandria C. Murphy
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  2. Melanie R. McReynolds
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Corresponding author

Correspondence to Melanie R. McReynolds.

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The authors declare no competing financial interests.

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Murphy, A.C., McReynolds, M.R. Toying with reductive stress. Nat Chem Biol 20, 542–543 (2024). https://doi.org/10.1038/s41589-023-01461-9

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  • DOI: https://doi.org/10.1038/s41589-023-01461-9

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