Newly developed synthetic antibodies offer the means to be used as high-affinity, conformation-specific probes to capture dynamic repertoires of neddylated cullin–RING E3 ligase complexes. This allows nonenzymatic profiling of the diverse signaling networks that are based on these active complexes.
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Parui, A.L., Walden, H. Hunting down the shapeshifters. Nat Chem Biol 19, 1438–1439 (2023). https://doi.org/10.1038/s41589-023-01407-1
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DOI: https://doi.org/10.1038/s41589-023-01407-1
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