Tricyclic peptides have reduced conformational flexibility, making them well suited for ligand development. Researchers have now generated large combinatorial libraries of tricyclic peptides using a disulfide-directing motif. Screening these libraries discovered binders to challenging protein targets.
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References
Daly, N. L. & Craik, D. J. Curr. Opin. Chem. Biol. 15, 362–368 (2011).
Hansen, S. et al. Proc. Natl. Acad. Sci. 119, (2022).
Lu, S. et al. J. Am. Chem. Soc. 145, 1964–1972 (2023).
Wu, C., Leroux, J.-C. & Gauthier, M. A. Nat. Chem. 4, 1044–1049 (2012).
Lu, S. et al. J. Am. Chem. Soc. 142, 16285–16291 (2020).
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Heinis, C. Motifs for making tricycles. Nat Chem Biol 19, 799–800 (2023). https://doi.org/10.1038/s41589-023-01329-y
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DOI: https://doi.org/10.1038/s41589-023-01329-y
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