Biased signaling gives hormones, probes or drugs distinct functional outcomes via the same receptor. The Biased Signaling Atlas (https://BiasedSignalingAtlas.org) provides a community hub with data and tools to advance this paradigm, which may yield safer and more potent drugs.
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Data availability
All data are available in the online Biased Signaling Atlas (https://BiasedSignalingAtlas.org) and GitHub (https://github.com/protwis/gpcrdb_data). Documentation is available at http://docs.biasedsignalingatlas.org.
Code availability
All open-source code can be obtained from GitHub (https://github.com/protwis/protwis) under the permissive Apache 2.0 License (https://www.apache.org/licenses/LICENSE-2.0).
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Acknowledgements
This work was supported by grants from the Lundbeck Foundation (R313-2019-526) and the Novo Nordisk Foundation (NNF18OC0031226) to D.E.G. This article is based upon work from COST Action ERNEST (CA18133), supported by COST (European Cooperation in Science and Technology, www.cost.eu).
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Contributions
Conceptualization, D.E.G.; methodology, A.J.K. and D.E.G.; data curation, A.S.H., E.G., K.H., L.D. and S.G.; validation: A.J.K., D.E.G. and K.H.; writing: original draft, D.E.G.; writing: review and editing, all authors; visualization, D.E.G.; funding acquisition, D.E.G.; software, A.J.K., A.M. and J.C.; supervision, A.J.K., A.S.H, D.E.G. and K.H.
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Competing interests
D.E.G. and A.J.K. have part-time employments at Kvantify. After completing their contribution to this study, A.M. and S.G. moved to Novo Nordisk A/S. The remaining authors declare no competing interests.
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Caroli, J., Mamyrbekov, A., Harpsøe, K. et al. A community Biased Signaling Atlas. Nat Chem Biol 19, 531–535 (2023). https://doi.org/10.1038/s41589-023-01292-8
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DOI: https://doi.org/10.1038/s41589-023-01292-8
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