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Epigenetic mechanism

Paralog-specific recognition

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Substrate–inhibitor conjugation facilitates structural determination of the KDM2A/B-nucleosome complexes, which provides mechanistic insights into the nucleosomal H3K36 demethylation by KDM2A/B and reveals a paralog-specific nucleosome acidic patch recognition mechanism mediated by the N terminus of KDM2A but not KDM2B.

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Fig. 1: Chemical trapping strategy enables the cryo-EM determination of KDM2A/B bound to nucleosome.

References

  1. Patel, D. J. & Wang, Z. Annu. Rev. Biochem. 82, 81–118 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Shi, Y. & Whetstine, J. R. Mol. Cell 25, 1–14 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Hyun, K. et al. Exp. Mol. Med. 49, e324 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Spangler, C. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01256-y (2022).

  5. Tsukada, Y.-I. et al. Nature 439, 811–816 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Cheng, Z. et al. Genes Dev. 28, 1758–1771 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Qu, K. et al. Nature 610, 569–574 (2022).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, China

    Huasong Ai & Lei Liu

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  1. Huasong Ai
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  2. Lei Liu
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Correspondence to Lei Liu.

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The authors declare no competing interests.

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Ai, H., Liu, L. Paralog-specific recognition. Nat Chem Biol 19, 542–543 (2023). https://doi.org/10.1038/s41589-022-01241-x

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