GPCRs are selective for specific G-protein subtypes, thereby ensuring signaling fidelity. A new report finds that that empty-like G-protein mutants are promiscuously recognized by GPCRs, suggesting that receptors select cognate over non-cognate G proteins at steps preceding nucleotide release.
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Garcia-Marcos, M. Stickier G-protein conformations. Nat Chem Biol 19, 665–666 (2023). https://doi.org/10.1038/s41589-022-01239-5
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DOI: https://doi.org/10.1038/s41589-022-01239-5
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