Major hurdles remain in understanding the mechanisms of multidrug resistance (MDR) protein efflux. A new study uses deep mutational scanning of a bacterial MDR protein to determine the nature of its drug-binding cavity and understand its function and plasticity.
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Kaur, P. Deep dive into a drug pump. Nat Chem Biol 19, 393–394 (2023). https://doi.org/10.1038/s41589-022-01201-5
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DOI: https://doi.org/10.1038/s41589-022-01201-5
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