Skip to main content
SpringerLink
Log in

Metabolic engineering

A balancing act

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Inspired by nature, a synthetic carbon fixation cycle builds complex molecules directly from CO2. Building metabolism from the ground up requires several innovative advancements — now, a strategy to balance carbon demands in a complex metabolic network is explored.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Synthetic metabolism can enable the conversion of carbon dioxide into complex chemicals.

References

  1. Diehl, C., Gerlinger, P. D., Paczia, N. & Erb, T. J. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01179-0 (2022).

    Article  Google Scholar 

  2. Lee, S. Y. et al. Nat. Catal. 2, 18–33 (2019).

    Article  CAS  Google Scholar 

  3. Liew, F. E. et al. Nat. Biotechnol. 40, 335–344 (2022).

    Article  CAS  Google Scholar 

  4. Rasor, B. J. et al. Curr. Opin. Biotechnol. 69, 136–144 (2021).

    Article  CAS  Google Scholar 

  5. Schwander, T., von Borzyskowski, L. S., Burgener, S., Cortina, N. S. & Erb, T. J. Science 354, 900–904 (2016).

    Article  CAS  Google Scholar 

  6. Sundaram, S. et al. Angew. Chem. Intl Edn https://doi.org/10.1002/anie.202102333 (2021).

    Article  Google Scholar 

  7. Schultheisz, H. L., Szymczyna, B. R., Scott, L. G. & Williamson, J. R. ACS Chem. Biol. 3, 499–511 (2008).

    Article  CAS  Google Scholar 

  8. Zhang, J. et al. Nature 609, 341–347 (2022).

    Article  CAS  Google Scholar 

  9. Opgenorth, P. H., Korman, T. P., Iancu, L. & Bowie, J. U. Nat. Chem. Biol. 13, 938–942 (2017).

    Article  CAS  Google Scholar 

  10. Sun, J., Jeffryes, J. G., Henry, C. S., Bruner, S. D. & Hanson, A. D. Metab. Eng. 44, 150–159 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA

    Grant M. Landwehr & Michael C. Jewett

  2. Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA

    Grant M. Landwehr & Michael C. Jewett

  3. Center for Synthetic Biology, Northwestern University, Evanston, IL, USA

    Grant M. Landwehr & Michael C. Jewett

  4. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA

    Michael C. Jewett

  5. Simpson Querrey Institute, Northwestern University, Chicago, IL, USA

    Michael C. Jewett

Authors
  1. Grant M. Landwehr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael C. Jewett
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael C. Jewett.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Landwehr, G.M., Jewett, M.C. A balancing act. Nat Chem Biol 19, 127–128 (2023). https://doi.org/10.1038/s41589-022-01183-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-022-01183-4

  • Springer Nature America, Inc.

Search

Navigation