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Neurotransmitter biosynthesis

A gut feeling

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Unbiased metabolomics revealed the conversion of serotonin into N-acetylserotonin-derived glucosides by an intestinal carboxylesterase in Caenorhabditis elegans, which suggests an unappreciated role of the gut in modulating 5-HT signaling.

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Fig. 1: Biosynthesis of serotonin glucosides in C. elegans.

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  1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA

    Ji Y. Sze

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  1. Ji Y. Sze
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Correspondence to Ji Y. Sze.

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Sze, J.Y. A gut feeling. Nat Chem Biol 19, 125–126 (2023). https://doi.org/10.1038/s41589-022-01152-x

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