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Antifungal resistance

Sterol homeostasis in yeast

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The fungal sterol receptor and transcription factor Upc2 activates the transcription of ergosterol biosynthesis genes in response to ergosterol depletion in yeast. A structural and biochemical study reveals an Hsp90-dependent translocation activation mechanism of Upc2, with implications for triazole antifungal resistance.

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Fig. 1: Schematic model of sterol sensing and transcriptional regulation by Upc2.

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Authors and Affiliations

  1. Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA

    P. David Rogers

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  1. P. David Rogers
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Correspondence to P. David Rogers.

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Rogers, P.D. Sterol homeostasis in yeast. Nat Chem Biol 18, 1170–1171 (2022). https://doi.org/10.1038/s41589-022-01143-y

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