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MEMBRANE TRANSPORTERS

A (Fab)ulous tool to block efflux

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The cryo-electron microscopy structure of a fluoroquinolone efflux transporter, NorA, in complex with an antibody fragment provides a new strategy whereby peptide inhibitors derived from antibody loops could be used to block antibiotic efflux in a drug-resistant superbug.

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Fig. 1: Cryo-EM structure of NorA bound to an antibody fragment.

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  1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

    Aravind Penmatsa

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  1. Aravind Penmatsa
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Correspondence to Aravind Penmatsa.

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Penmatsa, A. A (Fab)ulous tool to block efflux. Nat Chem Biol 18, 681–682 (2022). https://doi.org/10.1038/s41589-022-00999-4

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