Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.
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Yu, W., Baskin, J.M. There is a lock for every key. Nat Chem Biol 17, 1214–1216 (2021). https://doi.org/10.1038/s41589-021-00908-1
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DOI: https://doi.org/10.1038/s41589-021-00908-1
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