Ferroptosis is a regulated form of non-apoptotic cell death implicated in pathological settings. To be exploited clinically, ferroptosis requires reagents that unequivocally detect ferroptosis in human and animal tissues. Such tools may enable development of ferroptosis-based medicines for diverse diseases.
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K.H. declares no competing financial interest. B.R.S. is an inventor on patents and patent applications involving ferroptosis, co-founded and serves as a consultant to Inzen Therapeutics and Nevrox Limited, and serves as a consultant to Weatherwax Biotechnologies Corporation.
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Peer review information Nature Chemical Biology thanks Jose Pedro Friedmann Angeli, Yilong Zou and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Hadian, K., Stockwell, B.R. A roadmap to creating ferroptosis-based medicines. Nat Chem Biol 17, 1113–1116 (2021). https://doi.org/10.1038/s41589-021-00853-z
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DOI: https://doi.org/10.1038/s41589-021-00853-z
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