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CHROMATIN BIOLOGY

Oncohistones: corruption at the core

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High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.

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Fig. 1: Globular domain oncohistone mutations and the cellular processes they affect.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC, USA

    Kanishk Jain & Brian D. Strahl

  2. Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Kanishk Jain & Brian D. Strahl

Authors
  1. Kanishk Jain
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  2. Brian D. Strahl
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Correspondence to Brian D. Strahl.

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The authors declare no competing interests.

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Jain, K., Strahl, B.D. Oncohistones: corruption at the core. Nat Chem Biol 17, 370–371 (2021). https://doi.org/10.1038/s41589-021-00764-z

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