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METABOLISM

Bariatric surgery works through a novel bile acid

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Bariatric surgery causes high rates of remission of type 2 diabetes; however, the mechanisms remain unresolved. A new study identifies cholic-acid-7-sulfate as a novel contributor to the metabolic benefits of bariatric surgery and an attractive target for treatment of type 2 diabetes.

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Fig. 1: CA7S is a novel TGR5 agonist upregulated by SG.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA

    Bethany P. Cummings

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  1. Bethany P. Cummings
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Correspondence to Bethany P. Cummings.

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Cummings, B.P. Bariatric surgery works through a novel bile acid. Nat Chem Biol 17, 5–6 (2021). https://doi.org/10.1038/s41589-020-0648-0

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