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A two-pronged attack

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Targeted small-molecule inhibition of BRAFV600E faces seemingly insurmountable obstacles in the clinic, such as rapid emergence of drug resistance. A recent study illustrates the potential of an alternative therapeutic strategy via PROTAC-mediated degradation of the oncogenic BRAF.

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Fig. 1: BRAF small-molecule inhibition vs. PROTAC-mediated degradation.

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Authors and Affiliations

  1. Department of Chemistry & Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA

    Joshua J. Feng & Chao Zhang

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  1. Joshua J. Feng
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  2. Chao Zhang
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Correspondence to Chao Zhang.

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Competing interests

C.Z. is a stockholder and consultant to BridGene Biosciences.

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Feng, J.J., Zhang, C. A two-pronged attack. Nat Chem Biol 16, 1154–1155 (2020). https://doi.org/10.1038/s41589-020-0647-1

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