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GPCR SIGNALING

Leveraging bias to your advantage

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Characterization of biased receptor signaling has ushered in opportunities for unprecedented control of G-protein-coupled receptors. Elucidation of distinct M1 muscarinic acetylcholine receptor signaling pathways and development of biased ligands may offer novel and safer Alzheimer’s disease therapeutics.

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Fig. 1: Probing the signaling pathway(s) that mediate the effects of M1 mAChR modulation.

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Authors and Affiliations

  1. Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA

    Sean P. Moran & P. Jeffrey Conn

  2. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA

    Sean P. Moran & P. Jeffrey Conn

  3. Department of Pharmacology, Vanderbilt University, Nashville, TN, USA

    P. Jeffrey Conn

Authors
  1. Sean P. Moran
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  2. P. Jeffrey Conn
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Correspondence to P. Jeffrey Conn.

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The authors declare no competing interests

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Moran, S.P., Conn, P.J. Leveraging bias to your advantage. Nat Chem Biol 16, 226–227 (2020). https://doi.org/10.1038/s41589-020-0468-2

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  • DOI: https://doi.org/10.1038/s41589-020-0468-2

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