The ADGRL3 receptor, a member of the adhesion G-protein-coupled receptor family, is implicated in many neurological diseases. Using a novel technique involving controlled proteolysis of the receptor’s extracellular domain, this study demonstrated that ADGRL3 signals via G12/13 G proteins.
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Gurevich, E.V., Gurevich, V.V. Designer adhesion GPCR tells its signaling story. Nat Chem Biol 16, 1280–1281 (2020). https://doi.org/10.1038/s41589-020-00673-7
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DOI: https://doi.org/10.1038/s41589-020-00673-7
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