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mTORC1 SIGNALING

Clearing debris

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A new small molecule that targets the vacuolar H+-ATPase activates autophagy, inhibits mTORC1 signaling, and displays potential for clearing toxic protein aggregates involved in neurodegenerative diseases.

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Fig. 1: EN6 promotes autophagy by enhancing vacuolar H+-ATPase (v-ATPase) activity and inhibiting mTORC1 signaling.

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Authors and Affiliations

  1. Department of Molecular Biology University of Texas Southwestern Medical Center, Dallas, TX, USA

    Delong Meng & Jenna L. Jewell

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  1. Delong Meng
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  2. Jenna L. Jewell
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Correspondence to Jenna L. Jewell.

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The authors declare no competing interests.

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Meng, D., Jewell, J.L. Clearing debris. Nat Chem Biol 15, 760–761 (2019). https://doi.org/10.1038/s41589-019-0320-8

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