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BACTERIAL-WORM INTERACTIONS

Harvesting Moco

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The molybdenum cofactor (Moco) is a fragile prosthetic group essential for most organisms. Nematodes are now capable of extracting Moco from their bacterial diet to mediate detoxification of sulfite.

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Fig. 1: Interkingdom transfer of the prosthetic group molybdenum cofactor (Moco) and its precursor cPMP from the bacterium E. coli to the nematode C. elegans.

References

  1. Schwarz, G., Mendel, R. R. & Ribbe, M. W. Nature 460, 839–847 (2009).

    Article  CAS  PubMed  Google Scholar 

  2. Mendel, R. R. J. Biol Chem. 288, 13165–13172 (2013).

    CAS  Google Scholar 

  3. Warnhoff, K. & Ruvkun, G. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0249-y (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Johnson, J. L. Prenat. Diagn. 23, 6–8 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. Gunnison, A. F. Food Cosmet. Toxicol. 19, 667–682 (1981).

    Article  CAS  PubMed  Google Scholar 

  6. Sinclair, J. & Hamza, I. Biometals 28, 481–489 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Veldman, A. et al. Pediatrics 125, 1249–1257 (2010).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Plant Biology, Braunschweig University of Technology, Braunschweig, Germany

    Ralf R. Mendel & Thomas W. Hercher

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  1. Ralf R. Mendel
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  2. Thomas W. Hercher
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Correspondence to Ralf R. Mendel.

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The authors declare no competing interests.

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Mendel, R.R., Hercher, T.W. Harvesting Moco. Nat Chem Biol 15, 429–430 (2019). https://doi.org/10.1038/s41589-019-0257-y

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