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Fast bioelectrical switches

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Faster-than-transcription control of cellular activities is an important but challenging engineering target. Using split ferredoxins and induced dimerization or conformational changes, newly developed metalloprotein switches provide a fast method to control electron flux.

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Fig. 1: Metalloprotein switches for post-translational control of electron flow.

References

  1. Cameron, D. E., Bashor, C. J. & Collins, J. J. Nat. Rev. Microbiol. 12, 381–390 (2014).

    Article  CAS  Google Scholar 

  2. Taylor, N. D. et al. Nat. Methods 13, 177–183 (2016).

    Article  CAS  Google Scholar 

  3. Rosenfeld, N., Elowitz, M. B. & Alon, U. J. Mol. Biol. 323, 785–793 (2002).

    Article  CAS  Google Scholar 

  4. Atkinson, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0192-3 (2019).

    Article  Google Scholar 

  5. Stein, V. & Alexandrov, K. Trends Biotechnol. 33, 101–110 (2015).

    Article  CAS  Google Scholar 

  6. Tantama, M. & Yellen, G. Methods Enzymol. 547, 355–371 (2014).

    Article  CAS  Google Scholar 

  7. Hung, Y. P., Albeck, J. G., Tantama, M. & Yellen, G. Cell Metab. 14, 545–554 (2011).

    Article  CAS  Google Scholar 

  8. TerAvest, M. A. & Ajo-Franklin, C. M. Biotechnol. Bioeng. 113, 687–697 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Michaela TerAvest.

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TerAvest, M. Fast bioelectrical switches. Nat Chem Biol 15, 99–100 (2019). https://doi.org/10.1038/s41589-018-0212-3

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