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Structures shed light on prostanoid signaling

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Prostanoids signal through G-protein-coupled receptors to regulate diverse physiological processes. Structures of three prostanoid receptors in inactive and active conformations now uncover the molecular determinants of ligand recognition and receptor activation and offer new opportunities for drug discovery.

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Fig. 1: Prostanoid receptor agonists and antagonists.
Fig. 2: Receptor structure and ligand binding.

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  1. Merck & Co., Inc., West Point, PA, USA

    Kaspar Hollenstein

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  1. Kaspar Hollenstein
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Correspondence to Kaspar Hollenstein.

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The author declares no competing interests.

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Hollenstein, K. Structures shed light on prostanoid signaling. Nat Chem Biol 15, 3–5 (2019). https://doi.org/10.1038/s41589-018-0178-1

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