Scientists have combined functional and computational analysis to predict the substrate specificity of a family of glycosyltransferases from Arabidopsis thaliana, creating a tool that enables researchers to classify the donor and acceptor specificity of glycosyltransferase enzymes.
References
Lairson, L. L., Henrissat, B., Davies, G. J. & Withers, S. G. Annu. Rev. Biochem. 77, 521–555 (2008).
Gantt, R. W., Peltier-Pain, P., Singh, S., Zhou, M. & Thorson, J. S. Proc. Natl. Acad. Sci. USA 110, 7648–7653 (2013).
Coutinho, P. M., Deleury, E., Davies, G. J. & Henrissat, B. J. Mol. Biol. 328, 307–317 (2003).
Yang, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0154-9 (2018).
Lombard, V., Golaconda Ramulu, H., Drula, E., Coutinho, P. M. & Henrissat, B. Nucleic Acids Res. 42, D490–D495 (2014).
Gloster, T. M. Curr. Opin. Struct. Biol. 28, 131–141 (2014).
Lim, E.-K. Glycobiology 13, 139–145 (2003).
Sánchez-Rodríguez, A. et al. BMC Genomics 15, 349 (2014).
Schmid, J., Heider, D., Wendel, N. J., Sperl, N. & Sieber, V. Front. Microbiol. 7, 182 (2016).
George Thompson, A. M., Iancu, C. V., Neet, K. E., Dean, J. V. & Choe, J. Y. Sci. Rep. 7, 46629 (2017).
Moreland, J. L., Gramada, A., Buzko, O. V., Zhang, Q. & Bourne, P. E. BMC Bioinformatics 6, 21 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Schmid, J. Divining sugar substrates. Nat Chem Biol 14, 1071–1072 (2018). https://doi.org/10.1038/s41589-018-0165-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-018-0165-6
- Springer Nature America, Inc.