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CANCER METABOLISM

New tricks for an old drug

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The prodrug dimethyloxalylglycine (DMOG) is a well-known tool compound used to study hypoxia. New findings reveal that DMOG also inhibits glutamine metabolism and can be exploited to selectively kill some cancer cells, highlighting important caveats when using DMOG for hypoxia studies.

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Fig. 1: DMOG metabolism and inhibitory activities.

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Authors and Affiliations

  1. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA

    Barbara S. Nelson, Daniel M. Kremer & Costas A. Lyssiotis

  2. Rogel Cancer Center and Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA

    Costas A. Lyssiotis

Authors
  1. Barbara S. Nelson
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  2. Daniel M. Kremer
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  3. Costas A. Lyssiotis
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Correspondence to Costas A. Lyssiotis.

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The authors declare no competing interests.

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Nelson, B.S., Kremer, D.M. & Lyssiotis, C.A. New tricks for an old drug. Nat Chem Biol 14, 990–991 (2018). https://doi.org/10.1038/s41589-018-0137-x

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