Skip to main content
Log in

AMYLOID STRUCTURE

Mimicking cross-α amyloids

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

The design of spiraling cross-α amyloid-like structures reveals fascinating supermolecular fibrils of diverse compactness and stability. The small sequence variations governing cross-α self-assembly properties concur with amyloids being basic building blocks of life and natural targets for microbial structural mimicry.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Polymorphic amyloid-like fibrils and structural mimicry.

References

  1. Eisenberg, D. S. & Sawaya, M. R. Annu. Rev. Biochem. 86, 69–95 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Salinas, N., Colletier, J. P., Moshe, A. & Landau, M. Nat. Commun. (in the press).

  3. Tayeb-Fligelman, E. et al. Science 355, 831–833 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Zhang, S.-Q. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0105-5 (2018).

  5. Hughes, M. P. et al. Science 359, 698–701 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Luo, F. et al. Nat. Struct. Mol. Biol. 25, 341–346 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Jacobs, M. D. & Harrison, S. C. Cell 95, 749–758 (1998).

    Article  CAS  PubMed  Google Scholar 

  8. Plückthun, A. Annu. Rev. Pharmacol. Toxicol. 55, 489–511 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Rout, S. K., Friedmann, M. P., Riek, R. & Greenwald, J. Nat. Commun. 9, 234 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Friedland, R. P. J. Alzheimers Dis. 45, 349–362 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Meytal Landau.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Landau, M. Mimicking cross-α amyloids. Nat Chem Biol 14, 833–834 (2018). https://doi.org/10.1038/s41589-018-0118-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-018-0118-0

  • Springer Nature America, Inc.

This article is cited by

Navigation