Calcium channels are crucial regulators of a broad range of biological processes. A photoswitchable chemical probe allows the opening and closing of these channels with unprecedented temporal resolution, providing new opportunities to study calcium-dependent signaling pathways in real time.
References
Fehrentz, F. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0090-8 (2018).
Szymański, W., Beierle, J. M., Kistemaker, H. A., Velema, W. A. & Feringa, B. L. Chem. Rev. 113, 6114–6178 (2013).
Hartley, G. S. Nature 140, 281 (1937).
Volgraf, M. et al. Nat. Chem. Biol. 2, 47–52 (2006).
Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymanski, W. & Feringa, B. L. Angew. Chem. Int. Edn. Engl. 55, 10978–10999 (2016).
Morad, M., Goldman, Y. E. & Trentham, D. R. Nature 304, 635–638 (1983).
Kang, S. K. et al. Nature 530, 71–76 (2016).
Fernandez, A. et al. ACS Cent. Sci. 3, 995–1005 (2017).
Klaue, K., Garmshausen, Y. & Hecht, S. Angew. Chem. Int. Edn. Engl. 57, 1414–1417 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Vendrell, M. A remote control for switching. Nat Chem Biol 14, 749–750 (2018). https://doi.org/10.1038/s41589-018-0107-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-018-0107-3
- Springer Nature America, Inc.