Bioengineers have used directed evolution to generate a new family of synthetic transcription factors based on the tryptophan repressor. The evolved repressor family enables researchers to build new gene circuits for biomedical applications.
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Brödel, A.K., Isalan, M. Trp-ing upon new repressors. Nat Chem Biol 14, 328–329 (2018). https://doi.org/10.1038/s41589-018-0012-9
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DOI: https://doi.org/10.1038/s41589-018-0012-9
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