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Exit from totipotency is controlled by DUXBL in mice

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In mice, zygotic genome activation occurs at onset of the two-cell stage in embryonic development and coincides with the exit from totipotency. Our work shows that the transcription factor DUXBL participates in silencing part of the stage-specific two-cell-associated transcriptional program and is required for development to proceed.

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Fig. 1: Recruitment of DUXBL to DUX binding sites silences the two-cell-stage-associated gene program.

References

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This is a summary of: Vega-Sendino, M. et al. The homeobox transcription factor DUXBL controls exit from totipotency. Nat. Genet. https://doi.org/10.1038/s41588-024-01692-z (2024).

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Exit from totipotency is controlled by DUXBL in mice. Nat Genet 56, 563–564 (2024). https://doi.org/10.1038/s41588-024-01690-1

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  • DOI: https://doi.org/10.1038/s41588-024-01690-1

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