Mutational signatures help to deconvolve the different processes that shape cancer genomes. A new tool now alleviates some of the persistent challenges in the field.
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References
Jin, H. et al. Nat. Genet. https://doi.org/10.1038/s41588-024-01659-0 (2024).
Nik-Zainal, S. et al. Cell 149, 979–993 (2012).
Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C., Campbell, P. J. & Stratton, M. R. Cell Rep. 3, 246–259 (2013).
Davies, H. et al. Nat. Med. 23, 517–525 (2017).
Koh, G., Degasperi, A., Zou, X., Momen, S. & Nik-Zainal, S. Nat. Rev. Cancer 21, 619–637 (2021).
Islam, S. M. A. et al. Cell Genom. 2, 100179 (2022).
Alexandrov, L. B. et al. Nature 578, 94–101 (2020).
Degasperi, A. et al. Nat. Cancer 1, 249–263 (2020).
Sondka, Z. et al. Nucleic Acids Res. 52, D1210–D1217 (2024).
Omichessan, H., Severi, G. & Perduca, V. PLoS ONE 14, e0221235 (2019).
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Nature 578, 82–93 (2020).
Drews, R. M. et al. Nature 606, 976–983 (2022).
Steele, C. D. et al. Nature 606, 984–991 (2022).
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Kaufmann, T.L., Schwarz, R.F. Improved identification of cancer mutational processes. Nat Genet 56, 365–366 (2024). https://doi.org/10.1038/s41588-024-01679-w
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DOI: https://doi.org/10.1038/s41588-024-01679-w
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