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Proteins shaping global chromatin accessibility

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Genome-wide CRISPR screening coupled with ATAC-see uncovered modulators that influence global chromatin accessibility. Notably, TFDP1 emerged as a pivotal modulator of chromatin accessibility that acts by controlling histone transcription. Depletion of TFDP1 induced a global elevation in accessibility, enhancing the efficiency of genome editing and iPS cell reprogramming.

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Fig. 1: Effect of knocking out screened hits on global chromatin accessibility and histone gene expression.

References

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This is a summary of: Ishii, S. et al. Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility. Nat. Genet. https://doi.org/10.1038/s41588-024-01658-1 (2024).

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Proteins shaping global chromatin accessibility. Nat Genet 56, 367–368 (2024). https://doi.org/10.1038/s41588-024-01667-0

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