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Spatial-omics analysis

Cellular neighborhood analysis in spatial omics reveals new tissue domains and cell subtypes

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Spatial omics enables the molecular profiling of cells with the tissue context preserved. A new analytic approach shows how cellular neighborhood analysis and feature augmentation can spatially connect and cluster millions of cells into higher-order functional units.

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Fig. 1: BANKSY neighbor augmentation.

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Acknowledgements

M.J.R. is supported by a Wings for Life Project Grant and a National Health and Medical Research Council (NHMRC) Project Grant (1163835). Q.N. is supported by an Australian Research Council DECRA Award (DE190100116), NHMRC Investigator Grant (GNT2008928) and NHMRC Project Grant (2001514).

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Authors and Affiliations

  1. School of Biomedical Science, Faculty of Medicine, The University of Queensland, Brisbane, Australia

    Marc J. Ruitenberg

  2. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia

    Quan H. Nguyen

  3. QIMR Berghofter Medical Research Institute, Brisbane, Australia

    Quan H. Nguyen

Authors
  1. Marc J. Ruitenberg
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  2. Quan H. Nguyen
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Correspondence to Quan H. Nguyen.

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The authors declare no competing interests.

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Ruitenberg, M.J., Nguyen, Q.H. Cellular neighborhood analysis in spatial omics reveals new tissue domains and cell subtypes. Nat Genet 56, 362–364 (2024). https://doi.org/10.1038/s41588-023-01646-x

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