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Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII

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Fig. 1: Schematics of the effects of RNAPII kinetics on intronic read distributions.

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Acknowledgements

A.G., J.P. and J.H.J.H. were supported by the European Research Council Advanced Grant Dam2Age, ONCODE (Dutch Cancer Society), the US National Institutes of Health (grant PO1 AG017242), Memorabel (ZonMW), the BBoL (NWO-ENW), the Deutsche Forschungsgemeinschaft (FOR 5504 project 496650118), EJP-RD project TC-NER RD20-113 and the Olav Thon Stiffelsen International Award to J.H.J.H. (2017). A.P. was supported by the Deutsche Forschungsgemeinschaft (SFB1565 project INST186/1479-1). A.P. and A.B. were supported by the Deutsche Forschungsgemeinschaft, Germany’s Excellence Strategy–CECAD, EXC 2030–390661388.

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Authors and Affiliations

  1. Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany

    Antonios Papadakis & Andreas Beyer

  2. Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands

    Akos Gyenis, Joris Pothof & Jan H. J. Hoeijmakers

  3. University of Cologne, Faculty of Medicine, Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), Institute for Genome Stability in Ageing and Disease, Cologne, Germany

    Akos Gyenis & Jan H. J. Hoeijmakers

  4. Princess Maxima Center for Pediatric Oncology, Oncode Institute, Utrecht, The Netherlands

    Jan H. J. Hoeijmakers

  5. Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany

    Argyris Papantonis

  6. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany

    Andreas Beyer

  7. Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany

    Andreas Beyer

Authors
  1. Antonios Papadakis
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  2. Akos Gyenis
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  4. Jan H. J. Hoeijmakers
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  5. Argyris Papantonis
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  6. Andreas Beyer
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Correspondence to Andreas Beyer.

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Papadakis, A., Gyenis, A., Pothof, J. et al. Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII. Nat Genet 55, 2011–2012 (2023). https://doi.org/10.1038/s41588-023-01601-w

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