The pancreas is an essential organ present in all vertebrates, and human pancreatic agenesis is an extremely rare disorder of largely unknown genetic determinants. A study now demonstrates that a primate-specific regulatory network controlled by the KRAB zinc-finger protein ZNF808 is essential for pancreas development.
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Rosspopoff, O., Martins, F. & Trono, D. New ingredients for old recipes. Nat Genet 55, 2023–2024 (2023). https://doi.org/10.1038/s41588-023-01591-9
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DOI: https://doi.org/10.1038/s41588-023-01591-9
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