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Linking non-coding variants to function in microglia in Alzheimer’s disease

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Genetic studies have associated thousands of non-coding variants with Alzheimer’s disease (AD), yet the functions of these variants remain elusive. We conducted cell-type-specific genetic fine mapping of AD variants and performed extensive functional characterization to unravel the causal variants that contribute to transcriptional regulation and AD­related phenotypes in microglia.

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Fig. 1: Proposed model linking AD risk variant rs7922621 to function in microglia.

References

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This is a summary of: Yang, X. et al. Functional characterization of Alzheimer’s disease genetic variants in microglia. Nat. Genet. https://doi.org/10.1038/s41588-023-01506-8 (2023).

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Linking non-coding variants to function in microglia in Alzheimer’s disease. Nat Genet 55, 1615–1616 (2023). https://doi.org/10.1038/s41588-023-01503-x

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