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Hematopoiesis

Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis

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In this issue of Nature Genetics, Lara-Astiaso et al. systematically characterized the functional roles of several chromatin factors in hematopoiesis by combining functional CRISPR screens with single-cell transcriptomics and chromatin accessibility profiling, revealing lineage biases and relationships with important transcription factors.

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Fig. 1: Perturbation of CFs uncovers essential regulatory networks for hematopoiesis.

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Authors and Affiliations

  1. Berlin Institute of Health (BIH), Charité–Universitätsmedizin Berlin, Berlin, Germany

    Llorenç Solé-Boldo & Simon Haas

  2. Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

    Llorenç Solé-Boldo & Simon Haas

  3. Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany

    Llorenç Solé-Boldo & Simon Haas

  4. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany

    Simon Haas

  5. Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ–ZMBH Alliance, Heidelberg, Germany

    Simon Haas

  6. German Cancer Consortium, Heidelberg, Germany

    Simon Haas

Authors
  1. Llorenç Solé-Boldo
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  2. Simon Haas
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Corresponding author

Correspondence to Simon Haas.

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The authors declare no competing interests.

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Solé-Boldo, L., Haas, S. Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis. Nat Genet 55, 1430–1431 (2023). https://doi.org/10.1038/s41588-023-01478-9

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  • DOI: https://doi.org/10.1038/s41588-023-01478-9

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