A novel pipeline that expands the utility of the protein language model ESM1b has provided variant effect predictions for more than 40,000 protein isoforms. This strategy outperformed several state-of-the-art methods over multiple benchmarks.
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Livesey, B.J., Marsh, J.A. Advancing variant effect prediction using protein language models. Nat Genet 55, 1426–1427 (2023). https://doi.org/10.1038/s41588-023-01470-3
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DOI: https://doi.org/10.1038/s41588-023-01470-3
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