Incidence of keratinocyte skin cancer varies markedly between populations living in different areas of the world. A detailed analysis of somatic mutations in the normal skin of individuals from the UK and Singapore reveals different patterns of clonal mutational landscapes that could contribute to differential risk.
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J.D. is supported by US Veterans Administration Merit Grant 1 I01 BX004495.
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De Dominici, M., DeGregori, J. Our ancestry dictates clonal architecture and skin cancer susceptibility. Nat Genet 55, 1428–1429 (2023). https://doi.org/10.1038/s41588-023-01467-y
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DOI: https://doi.org/10.1038/s41588-023-01467-y
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