How the chromatin states of transposable elements (TEs) are controlled in development and disease is unclear. We present CARGO-BioID, a CRISPR-based proteomic approach to identify TE-associated proteins, and reveal an interplay between RNA N6-methyladenosine (m6A) and DNA methylation that is crucial for regulating TE activation and human embryonic stem cell (hESC) fate.
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References
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This is a summary of: Sun, T. et al. Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells. Nat. Genet. https://doi.org/10.1038/s41588-023-01452-5 (2023).
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Regulation of transposable elements and stem cell fate by crosstalk between RNA and DNA methylation. Nat Genet 55, 1259–1260 (2023). https://doi.org/10.1038/s41588-023-01453-4
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DOI: https://doi.org/10.1038/s41588-023-01453-4
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