Skip to main content
SpringerLink
Log in

Human genetics

Leveraging family relatedness to detect participation bias in genetic studies

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Identifying the ways that a study sample is not representative is essential for maximizing the generalizability of findings to the population. A new method proposes discerning non-representativeness in large-scale genetic studies by comparing the genotypes of closely related participants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Genetic-induced participation bias through shared and not shared alleles.

References

  1. Fry, A. et al. Am. J. Epidemiol. 186, 1026–1034 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Delgado-Rodriguez, M. J. Epidemiol. Community Health 58, 635–641 (2004).

    Article  PubMed  Google Scholar 

  3. Martin, J. et al. Am. J. Epidemiol. 183, 1149–1158 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Taylor, A. E. et al. Int. J. Epidemiol. 47, 1207–1216 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Adams, M. J. et al. Int. J. Epidemiol. 49, 410–421 (2019).

    Article  Google Scholar 

  6. Tyrrell, J. et al. Nat. Commun. 12, 886 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Mignogna, G. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.02.11.480140 (2022).

  8. Pirastu, N. et al. Nat. Genet. 53, 663–671 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Schoeler, T. et al. Nat. Hum. Behav. https://doi.org/10.1038/s41562-023-01579-9 (2023).

    Article  PubMed  Google Scholar 

  10. Benonisdottir, S. & Kong, A. Nat. Genet. https://doi.org/10.1038/s41588-023-01439-2 (2023).

    Article  PubMed  Google Scholar 

  11. Martin, A. R. et al. Nat. Genet. 51, 584–591 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

    Mark J. Adams

Authors
  1. Mark J. Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark J. Adams.

Ethics declarations

Competing interests

The author has no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adams, M.J. Leveraging family relatedness to detect participation bias in genetic studies. Nat Genet 55, 1254–1255 (2023). https://doi.org/10.1038/s41588-023-01440-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-023-01440-9

  • Springer Nature America, Inc.

Search

Navigation