Interacting proteins commonly perform similar functions. A protein interaction network analysis of genes linked to 1,002 human traits identifies molecular mechanisms that are shared across traits and so-called pleiotropic biological processes, whose disruption might affect many aspects of human biology.
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References
Mills, M. C. & Rahal, C. A scientometric review of genome-wide association studies. Commun. Biol. 2, 9 (2019). A review article that presents relevant discoveries and evolution of GWAS since 2005.
Ghoussaini, M. & Mountjoy, E. Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. Nucleic Acids Res. 49, 1311–1320 (2021). This paper describes the Open Target Genetics Portal.
Choobdar, S. et al. Assessment of network module identification across complex diseases. Nat. Methods 16, 843–852 (2019). This paper benchmarks different methods for disease modules identification.
Federico, A. & Monti, S. Contextualized protein-protein interactions. Patterns (NY) 2, 1 (2020). This paper annotates interactions from the PPI database HIPPIE (http://cbdm.uni-mainz.de/hippie/) with biological context information (cell lines).
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This is a summary of: Barrio-Hernandez, I. et al. Network expansion of genetic associations defines a pleiotropy map of human cell biology. Nat. Genet. https://doi.org/10.1038/s41588-023-01327-9 (2023).
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A pleiotropy map of cell biology covering 1,002 human traits. Nat Genet 55, 365–366 (2023). https://doi.org/10.1038/s41588-023-01328-8
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DOI: https://doi.org/10.1038/s41588-023-01328-8
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